Mutagenic Consequences of Sublethal Cell Death Signaling

Many human cancers exhibit defects in key DNA damage response elements that can render tumors insensitive to the cell death-promoting properties of DNA-damaging therapies. Using agents directly induce apoptosis by targeting apoptotic components, rather than relying on indirectly stimulate cancer cells, may overcome classical blocks exploited cells evade death. However, there is increasing evidence surviving sublethal exposure signaling recover with newly acquired genomic changes which have oncogenic potential, and so could theoretically spur development subsequent cured patients. Encouragingly, necroptotic did not acquire mutations, suggesting necroptosis-inducing anti-cancer drugs be less likely trigger therapy-related cancers. We are yet develop effective direct inducers other death pathways, as such, data regarding consequences stimulation those pathways still emerging. This review details currently known mutagenic different implications for potential transformation. Understanding mechanisms mutagenesis associated (or not) various will guide us future therapeutics minimize side effects damage.